- 1 Arizona Cardinals vs Los Angeles Rams: an 18-16 October upset, and both lead receivers now gone
- 2 Arizona Cardinals: three points in Seattle and the first week of the Minshew era
- 3 Los Angeles Rams: three straight wins, Garrett back, Nacua and Adams out
- 4 Free NFL Prediction: Arizona Cardinals vs Los Angeles Rams
- 5 About our free predictions
- 6 No commitment from us
- 7 Information changes
- 8 Your responsibility
- 9 Responsible gambling
- 10 Legal age
- 11 About visuals
Arizona Cardinals vs Los Angeles Rams: an 18-16 October upset, and both lead receivers now gone 
Arizona won 18-16 at SoFi Stadium on 18 October, and the Rams lost more than the game that afternoon. Davante Adams injured his hamstring and went on injured reserve with an expected absence of six to ten weeks.
Four weeks later, Los Angeles have won three straight and moved to 5-4, but Puka Nacua is now expected to join Adams on injured reserve. Head coach Sean McVay said on Monday that Nacua has MCL and PCL sprains plus turf toe, which would sideline him for at least four games.
Arizona traded Jacoby Brissett to Baltimore on 6 November, and Gardner Minshew started in Seattle two days later. Arizona lost 17-3, and they’re 3-6 going into the rematch at State Farm Stadium on Sunday 15 November, kickoff 4:05pm ET on CBS.
The Rams are 9.5-point favourites, priced at 1.24 on the moneyline, with Arizona at 4.30. The total is set at 39.5 points, low for a game with a home defense allowing 28.3 a game, and we think the number is still too high given what both offenses have lost.
Our focus is the points line rather than the spread. Arizona haven’t won at home in three attempts this season, but the Rams’ passing game is about to lose the player who drew 19 of Matthew Stafford’s 43 attempts last Sunday.
Arizona Cardinals: three points in Seattle and the first week of the Minshew era 
Seattle played without Sam Darnold on 8 November, and Drew Lock completed 19 of 28 passes for 175 yards. Arizona still managed one field goal, and the Cardinals’ best chance at a touchdown ended when Seattle defended Minshew’s fourth-and-goal pass to Trey McBride from the 2.
Minshew’s season totals reflect a backup’s workload: 38 of 53 for 354 yards and three touchdowns. Brissett’s departure brought Arizona a 2027 fourth-round pick and a 2028 seventh-rounder, with a 2027 fifth also going to Baltimore in the deal.
Tight end Trey McBride carries the offense with 73 catches for 598 yards and five touchdowns, and Tyler Allgeier leads the backs with 369 rushing yards and two scores. Running back Bam Knight is questionable with a concussion, and two linemen, Jayden Williams and Jon Gaines II, are also questionable.
Arizona lost 45-21 at home to Detroit and 30-16 at home to Denver, and they won 33-30 in overtime in Dallas on 1 November. All three of their wins have come on the road, and they’re 0-3 in Glendale.
On defense they’ve allowed 255 points in nine games. Budda Baker leads the team with 3.5 sacks and Jack Gibbens has 64 tackles, and the unit held the Rams to 16 points in the first meeting.
no renewal
Free for 2 weeks.
Los Angeles Rams: three straight wins, Garrett back, Nacua and Adams out 
Nacua caught 14 passes for 150 yards and a touchdown in the 20-13 win in Landover. He has 70 catches for 715 yards and four touchdowns this season and accounted for 27.6% of the Rams’ targets, the eighth-highest share in the league.
The next options are a running back and two tight ends. Kyren Williams has 46 targets and 36 catches to go with 593 rushing yards and six touchdowns, Tyler Higbee has 287 receiving yards and Davis Allen has two receiving touchdowns.
Stafford has thrown 16 touchdowns and nine interceptions this season. Against Washington he went 26 of 43 for 219 yards with an interception, and the Rams’ last two wins finished 24-9 and 20-13.
The defense is the reason for the winning run. Myles Garrett had three sacks and a forced fumble in his return on 8 November, and Washington managed a single field goal in the final 44 minutes. Byron Young has 4.5 sacks and Nate Landman leads the team with 66 tackles.
Cornerback Trent McDuffie is questionable with a back injury. Los Angeles have allowed 181 points, 20.1 per game, and they’re 3-1 on the road this season. Two of their three home defeats came in a five-day span in October: 37-34 in overtime to Buffalo on 13 October and 18-16 to Arizona on 18 October.
Probable lineup Arizona Cardinals: QB Gardner Minshew II, RB Tyler Allgeier, TE Trey McBride; defense led by Budda Baker and Jack Gibbens. Final lineup not announced at time of publication.
Probable lineup Los Angeles Rams: QB Matthew Stafford, RB Kyren Williams, TE Tyler Higbee, TE Davis Allen (Puka Nacua and Davante Adams out); defense led by Myles Garrett, Byron Young and Nate Landman. Final lineup not announced at time of publication.
Free NFL Prediction: Arizona Cardinals vs Los Angeles Rams
Our prediction: Under 39.5 points (1.89)
The first meeting produced 34 points, with Adams on the field for part of it and Brissett still on Arizona’s roster. Since then Arizona have swapped Brissett for Minshew and scored three points in his first start, while the Rams’ last two games produced 33 points each.
Arizona’s defense has conceded 28.3 a game, and that’s the risk to this pick. The Rams without Nacua and Adams are a different offense, though, built around Williams and two tight ends, and that profile tends to shorten games and drain the clock.
Garrett’s return gives the Rams a pass rush to pressure a quarterback who has thrown 53 passes all season. We expect a slow, low-scoring game and we’re taking the under.
in your pocket.
Real-time notifications & alerts
_________
About our free predictions
- What we publish on MathOdds are analyses, nothing more. We share a view, a reading of the moment, but never a guarantee. Sport remains what it is: unpredictable. A red card, an injury, a last-minute goal, and the script changes completely.
- Let’s be clear: there is no such thing as a risk-free bet. Even when it looks “obvious”, nothing ever is. And yes, that means you can lose. It’s even inevitable at some point.
- The smartest approach is to stay reasonable. Bet small, set a budget and stick to it. Never use money you need to live on. And above all: don’t chase your losses: that rarely ends well.
- A bet should remain a game, not a job or a source of income. If it starts taking up too much space in your daily life, causes stress or frustration, take a break. And if needed, talk to a support organisation: that’s what they’re there for.
- Ultimately, responsibility lies with you. Reading our content means accepting that risk exists and will never disappear, no matter how good the analysis.
- Essential reminder: gambling is prohibited for minors and must comply with the laws of your country. Need help? Visit begambleaware.org.
No commitment from us
Our predictions carry no contractual value. They have no legal standing. In short: you cannot rely on them to claim anything if a bet doesn’t come through.
Information changes
A prediction is always based on what we know at the time of writing. But between publication and kick-off, a lineup can change, a player picks up an injury, the weather turns, and the analysis can quickly be outdated. We cannot be held responsible for that.
Your responsibility
Before placing a bet, simply check that gambling is legal in your country. If it isn’t, that’s your responsibility, not ours.
Responsible gambling
We can’t say it enough: gamble responsibly. If you’re struggling to stay in control, don’t wait to seek help.
Legal age
MathOdds content is intended for adults only. By browsing here, you confirm you meet the legal age requirement for gambling in your jurisdiction.
About visuals
The images and logos of Arizona Cardinals and Los Angeles Rams on MathOdds are used solely to illustrate our articles. They do not imply any official affiliation with a federation or sports organisation, and we claim no rights over them. Those rights belong to their original owners. If any visual raises a concern, contact us and it will be removed without delay.
Leave a Reply