Philadelphia Eagles vs San Francisco 49ers - Free NFL prediction and picks - January 11, 2026

Philadelphia Eagles vs San Francisco 49ers – Free NFL prediction and picks – January 11, 2026

Match context Philadelphia Eagles vs San Francisco 49ers National Football League - Wikipedia

Eagles vs Niners! A playoff clash between two teams arriving with very different momentum. Philly purposely eased off last week — a near-bye that leaves them rested and firing on all cylinders. By contrast, San Francisco just came out of a brutal game with Seattle; it’s left some marks ahead of a tough trip to the East Coast.

In January, that freshness gap matters big time, especially at Lincoln Financial Field, where the Eagles tend to lift their game in the postseason.

Matchup keys Philadelphia Eagles vs San Francisco 49ers Philadelphia Eagles vs San Francisco 49ers

First key is the line of scrimmage. Philly should get Lane Johnson back, which further bolsters an already dominant offensive line. Facing a 49ers front seven that’s weakened — possibly missing multiple starters — the advantage is firmly with the Eagles.

For San Francisco, Brock Purdy’s condition remains a genuine concern. Hurt late last week, he’s expected to play, but taking on an aggressive, fresh defense while carrying a knock is far from ideal. Philly knows exactly how to exploit that — as we saw in their last playoff meeting.

Game scenario Philadelphia Eagles vs San Francisco 49ers

Everything points to a game controlled by the Eagles. Philly should impose a physical tempo, limit opponent possessions and force San Francisco to play from behind. The 49ers have the talent to hang around for a while, but accumulated injuries and fatigue will likely bite in the second half.

The total has sensibly dropped, and the setup argues for a tight game — few big plays, lots of running and clock control.

Bouton PenseBet

Free Pick Philadelphia Eagles vs San Francisco 49ers

Pick: Philadelphia Eagles -3,5

Between freshness, home-field edge and clear superiority in the trenches, Philadelphia ticks too many boxes to ignore. San Francisco will have to play an almost-perfect game to pull off an upset.

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