San Francisco 49ers vs Carolina Panthers - Free NFL pick and predictions - November 24, 2025

San Francisco 49ers vs Carolina Panthers – Free NFL pick and predictions – November 24, 2025

49ers – Panthers: Monday Night Football main event National Football League — Wikipédia

Levi’s Stadium will light up Monday for a clash that could tilt the rest of the season. The 49ers host Carolina. Different ambitions. Both arrive with enough certainty to make this look tighter than it should be.

49ers back in form Fichier:San Francisco 49ers logo.svg — Wikipédia

The 49ers have long been navigating a division where every slip costs. Seven wins, four losses, and they’re still within striking distance of Los Angeles. The picture isn’t perfect, but the goal hasn’t been lost. Their strength is the passing game firing on all cylinders. Second-best passing attack in the league, San Francisco scores 23.7 points per game on average — enough to keep pace despite a season scarred by injuries.

Last week in Arizona they did what big teams do: take every inch. A solid first half, three turnovers, and a convincing 41-22 win, even while being outgained in total yards (488 to 281). That quick-strike then control trait is vintage San Francisco.

Brock Purdy, out the last few weeks with a foot issue, is back and back in rhythm. Two hundred yards passing, two touchdowns, a clean game, no dramatics. Beside him, Christian McCaffrey did Christian McCaffrey things: 81 yards, a TD, a constant influence that drags defenders out of position.

Panthers moving at Bryce Young’s pace Panthers de la Caroline — Wikipédia

The Panthers are still hard to read. A winning record, but enough inconsistency to force weekly checks. They can lose at home to the Saints, then go beat Atlanta in a tight game. They can light up the air or be silenced from whistle to whistle.

In Atlanta, Bryce Young produced the kind of game fans wanted. 448 passing yards, three touchdowns, a tempo that bullied the Falcons from the first drive to the last. In his wake, Tetairoa McMillan (130 yards, two TDs) and Xavier Legette (83 yards, one TD) turned the night into a statement.

The NFC South is still wide open. Carolina sits one win behind Tampa Bay. The road is long, but the Panthers have shown they can deliver when it matters. The issue is repetition. A brilliant week can be followed by a flat performance. That’s the difference between a good team and a genuinely dangerous one.


Bouton PenseBet

NFL pick San Francisco 49ers vs Carolina Panthers

Under 49.5 points

The Panthers can bother the 49ers, but don’t expect an all-out shootout. Both teams have weapons and weak spots that can slow the pace. Levi’s Stadium can cool down momentum. A tighter, more tactical affair than an explosive one looks most likely.

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