Cincinnati Bengals vs Arizona Cardinals - Free NFL prediction and picks - December 28, 2025

Cincinnati Bengals vs Arizona Cardinals – Free NFL prediction and picks – December 28, 2025

Match context: Cincinnati Bengals vs Arizona Cardinals  National Football League — Wikipédia

Arizona comes into this one with nothing real to play for in the standings and obvious structural issues. After a 2–0 start the Cardinals have collapsed, piling up losses while the defense keeps leaking. Kyler Murray is out for the rest of the season and Jacoby Brissett runs a mostly aerial attack — high volume, but with almost no support from the ground game.

Cincinnati, by contrast, finishes the season much sharper since Joe Burrow returned. The Bengals are still up and down, but the offense has found rhythm again, shown by that offensive clinic against Miami last week. The season’s a write-off overall, but Cincinnati’s been playing far better for several weeks.

Key factors in the Cincinnati Bengals Cincinnati Bengals - Wikipedia vs Arizona Cardinals Arizona Cardinals - Wikipedia

The defining factor is the mismatch between the Bengals’ passing attack and the Cardinals’ defense. Arizona gives up huge yardage and points, especially through the back seven, and Joe Burrow arrives full of confidence with a trio of receivers ready to punish any mistake.

Arizona can score through the air — the Bengals’ defense is one of the most permissive in the league, especially versus the pass. Brissett should find Trey McBride and the intermediate targets regularly. But the lack of a running game and the defense’s inability to get stops will likely doom the Cardinals over the long haul.

Free NFL prediction Cincinnati Bengals vs Arizona Cardinals

Over 50.5 total points in the game.

Everything points to an open, high-scoring game. Cincinnati has too many weapons and faces an Arizona defense in real trouble, while the Cardinals still have receiving talent that will add to the scoreboard. The gap should widen gradually in favor of the Bengals.

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