Context of the Arizona Cardinals vs San Francisco 49ers match 
San Francisco arrives in Arizona in an unstable context to challenge the Cardinals, still shaken by injuries and without a real offensive backbone. Brock Purdy returns, possibly with Ricky Pearsall, but the momentum isn’t there. The severe setback faced against the Rams mainly revealed the shortcomings of a team that often lives beyond its means this season. Meanwhile, the Cardinals remain modest in the standings but surprisingly solid in the air, led by a Jacoby Brissett who is doing more than just filling in.
The keys to the Arizona Cardinals vs San Francisco 49ers duel 
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What intrigues most here is the contrast between the image the Niners project and what they actually produce. Defensively, they generate almost no pass rush, and their coverage no longer inspires the same fear. As a result: Brissett should have more time than usual, especially after a game where he survived five sacks against a much more threatening defense.
The other central point: Arizona defends the pass remarkably well this season. Ninth in DVOA, eighth in yards per attempt allowed, despite a light roster. Even a poor game against Seattle doesn’t change the trend. San Francisco, on the other hand, advances without stability both at the quarterback position and in the rotation of its playmakers. This weighs heavily, especially against a disciplined defense.
Free Predictions Arizona Cardinals vs San Francisco 49ers
Result: Arizona Cardinals +3.5
The Cardinals are far from perfect, but in this specific duel, the intensity, the matchup, and recent form favor them. Brissett has the means to keep pace against a 49ers defense that no longer intimidates, while Purdy returns in a messy environment.
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